Antisense Oligonucleotides

Antisense oligonucleotides ("ASOs") are synthetic polymers:

Antisense oligonucleotides are synthesized in the hope that they can be used as therapeutic agents — blocking disease processes by altering the synthesis of a particular protein. This would be achieved by the binding of the antisense oligonucleotide to the mRNA from which that protein is normally synthesized. Binding of the two may

In order to be useful in human therapy, antisense oligonucleotides must

To achieve these goals, antisense oligonucleotides are generally

A variety of antisense oligonucleotides are being tested as possible weapons against:

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27 March 2022